CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.70 | Cathepsin B; Chain A |
|
3.90.70.10 | Cysteine proteinases |
Domain Context
CATH Clusters
| Superfamily | Cysteine proteinases |
| Functional Family | Cruzipain |
Enzyme Information
| 3.4.22.51 |
Cruzipain.
based on mapping to UniProt P25779
Broad endopeptidase specificity similar to that of cathepsin L.
-!- Is located in the digestive vacuoles of the parasitic trypanosome and contributes to the nutrition of the organism by digestion of host proteins. -!- Belongs to peptidase family C1.
|
UniProtKB Entries (1)
| P25779 |
CYSP_TRYCR
Trypanosoma cruzi
Cruzipain
|
PDB Structure
| PDB | 1EWP |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Chapter 3: X-ray Structures of Complexes of Cruzain with Designed Covalent Inhibitors
Enzyme-ligand Interactions, Inhibition and Specificity
|