CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Malic enzyme

Enzyme Information

1.1.1.38
Malate dehydrogenase (oxaloacetate-decarboxylating).
based on mapping to UniProt P23368
(1) (S)-malate + NAD(+) = pyruvate + CO(2) + NADH. (2) Oxaloacetate = pyruvate + CO(2).
-!- Unlike EC 1.1.1.39, this enzyme can also decarboxylate oxaloacetate, cf. EC 1.1.1.40.

UniProtKB Entries (1)

P23368
MAOM_HUMAN
Homo sapiens
NAD-dependent malic enzyme, mitochondrial

PDB Structure

PDB 1EFK
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of a closed form of human malic enzyme and implications for catalytic mechanism.
Yang, Z., Floyd, D.L., Loeber, G., Tong, L.
Nat.Struct.Biol.