CATH Classification

Domain Context

CATH Clusters

Superfamily Medium-chain alcohol dehydrogenases, catalytic domain
Functional Family S-(hydroxymethyl)glutathione dehydrogenase

Enzyme Information

1.1.1.1
Alcohol dehydrogenase.
based on mapping to UniProt P00328
(1) A primary alcohol + NAD(+) = an aldehyde + NADH. (2) A secondary alcohol + NAD(+) = a ketone + NADH.
-!- Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. -!- The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.

UniProtKB Entries (1)

P00328
ADH1S_HORSE
Equus caballus
Alcohol dehydrogenase S chain

PDB Structure

PDB 1EE2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for substrate specificity differences of horse liver alcohol dehydrogenase isozymes.
Adolph, H.W., Zwart, P., Meijers, R., Hubatsch, I., Kiefer, M., Lamzin, V., Cedergren-Zeppezauer, E.
Biochemistry