CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Chymotrypsin-like elastase family member 1

Enzyme Information

3.4.21.36
Pancreatic elastase.
based on mapping to UniProt P00772
Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-Xaa.
-!- Formed by activation of proelastase from mammalian pancreas by trypsin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.7 and EC 3.4.21.11.

UniProtKB Entries (1)

P00772
CELA1_PIG
Sus scrofa
Chymotrypsin-like elastase family member 1

PDB Structure

PDB 1EAT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Nonpeptidic inhibitors of human leukocyte elastase. 5. Design, synthesis, and X-ray crystallography of a series of orally active 5-aminopyrimidin-6-one-containing trifluoromethyl ketones.
Veale, C.A., Bernstein, P.R., Bryant, C., Ceccarelli, C., Damewood Jr., J.R., Earley, R., Feeney, S.W., Gomes, B., Kosmider, B.J., Steelman, G.B., Thomas, R.M., Vacek, E.P., Williams, J.C., Wolanin, D.J., Woolson, S.
J.Med.Chem.