CATH Classification

Domain Context

CATH Clusters

Superfamily MurE/MurF, N-terminal domain
Functional Family UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase

Enzyme Information

6.3.2.13
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase.
based on mapping to UniProt P22188
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + meso-2,6- diaminoheptanedioate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L- alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate.
-!- Involved in the synthesis of a cell-wall peptide. -!- This enzyme adds diaminopimelate in Gram-negative organisms and in some Gram-positive organisms; in others EC 6.3.2.7 adds lysine instead. -!- It is the amino group of the L-center of the diaminopimelate that is acylated.

UniProtKB Entries (1)

P22188
MURE_ECOLI
Escherichia coli K-12
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase

PDB Structure

PDB 1E8C
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Udp-N-Acetylmuramoyl-L-Alanyl-D-Glutamate: Meso-Diaminopimelate Ligase from Escherichia Coli
Gordon, E.J., Flouret, B., Chantalat, L., Van Heijenoort, J., Mengin-Lecreulx, D., Dideberg, O.
J.Biol.Chem.