CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.1.1.363
Glucose-6-phosphate dehydrogenase (NAD(P)(+)).
based on mapping to UniProt P11411
D-glucose 6-phosphate + NAD(P)(+) = 6-phospho-D-glucono-1,5-lactone + NAD(P)H.
-!- The enzyme catalyzes a step of the pentose phosphate pathway. -!- The enzyme from the Gram-positive bacterium Leuconostoc mesenteroides prefers NADP(+) while the enzyme from the Gram-negative bacterium Gluconacetobacter xylinus prefers NAD(+). -!- Cf. EC 1.1.1.49 and EC 1.1.1.388.

UniProtKB Entries (1)

P11411
G6PD_LEUME
Leuconostoc mesenteroides
Glucose-6-phosphate 1-dehydrogenase

PDB Structure

PDB 1E77
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
An Examination of the Role of Asp-177 in the His-Asp Catalytic Dyad of Leuconostoc Mesenteroides Glucose 6-Phosphate Dehydrogenase: X-Ray Structure and Ph Dependence of Kinetic Parameters of the D177N Mutant Enzyme
Cosgrove, M.S., Gover, S., Naylor, C.E., Vandeputte-Rutten, L., Adams, M.J., Levy, H.R.
Biochemistry