CATH Classification

Domain Context

CATH Clusters

Superfamily Methyl-coenzyme M reductase, alpha/beta subunit, C-terminal
Functional Family

Enzyme Information

2.8.4.1
Coenzyme-B sulfoethylthiotransferase.
based on mapping to UniProt Q49605
Methyl-CoM + CoB = CoM-S-S-CoB + methane.
-!- This enzyme catalyzes the final step in methanogenesis, the biological production of methane. -!- This important anaerobic process is carried out only by methanogenic archaea. -!- The enzyme can also function in reverse, for anaerobic oxidation of methane. -!- The enzyme requires the hydroporphinoid nickel complex coenzyme F(430). -!- Highly specific for coenzyme B with a heptanoyl chain; ethyl CoM and difluoromethyl CoM are poor substrates. -!- The sulfide sulfur can be replaced by selenium but not by oxygen.

UniProtKB Entries (2)

Q49601
Q49601_9EURY
Methanopyrus kandleri
Methyl-coenzyme M reductase subunit beta
Q49605
MCRA_METKA
Methanopyrus kandleri AV19
Methyl-coenzyme M reductase I subunit alpha

PDB Structure

PDB 1E6V
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Comparison of Three Methyl-Coenzyme M Reductases from Phylogenetically Distant Organisms: Unusual Amino Acid Modification, Conservation and Adaptation
Grabarse, W., Mahlert, F., Shima, S., Thauer, R.K., Ermler, U.
J.Mol.Biol.