CATH Classification

Domain Context

CATH Clusters

Superfamily Carbohydrate-binding module superfamily 5/12
Functional Family

Enzyme Information

3.2.1.14
Chitinase.
based on mapping to UniProt P11797
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta- linkages in chitin and chitodextrins.
-!- The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo- chitodextrinases can act. -!- Activity is greatly stimulated in the presence of EC 1.14.99.53, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. -!- Cf. EC 3.2.1.202.

UniProtKB Entries (1)

P11797
CHIB_SERMA
Serratia marcescens
Chitinase B

PDB Structure

PDB 1E6N
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Insights Into the Catalytic Mechanism of a Family 18 Exo-Chitinase
Van Aalten, D.M.F., Komander, D., Synstad, B., Gseidnes, S., Peter, M.G., Eijsink, V.G.H.
Proc.Natl.Acad.Sci.USA