CATH Classification

Domain Context

CATH Clusters

Superfamily Alkaline Phosphatase, subunit A
Functional Family Arylsulfatase A

Enzyme Information

3.1.6.8
Cerebroside-sulfatase.
based on mapping to UniProt P15289
A cerebroside 3-sulfate + H(2)O = a cerebroside + sulfate.
-!- Hydrolyzes galactose-3-sulfate residues in a number of lipids. -!- Also hydrolyzes ascorbate 2-sulfate and many phenol sulfates.

UniProtKB Entries (1)

P15289
ARSA_HUMAN
Homo sapiens
Arylsulfatase A

PDB Structure

PDB 1E33
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Defective oligomerization of arylsulfatase a as a cause of its instability in lysosomes and metachromatic leukodystrophy.
von Bulow, R., Schmidt, B., Dierks, T., Schwabauer, N., Schilling, K., Weber, E., Uson, I., von Figura, K.
J. Biol. Chem.