CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family N-hydroxyarylamine O-acetyltransferase NhoA

Enzyme Information

2.3.1.118
N-hydroxyarylamine O-acetyltransferase.
based on mapping to UniProt Q00267
Acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine.
-!- The enzyme from liver, but not that from bacteria, can also catalyze N-acetylation of arylamines and N,O-acetylation of arylhydroxamates.
2.3.1.5
Arylamine N-acetyltransferase.
based on mapping to UniProt Q00267
Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.
-!- Wide specificity for aromatic amines, including serotonin; also catalyzes acetyl-transfer between arylamines without CoA.

UniProtKB Entries (1)

Q00267
NHOA_SALTY
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Arylamine N-acetyltransferase / N-hydroxyarylamine O-acetyltransferase

PDB Structure

PDB 1E2T
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of Arylamine N-Acetyltransferase Reveals a Catalytic Triad
Sinclair, J.C., Sandy, J., Delgoda, R., Sim, E., Noble, M.E.M.
Nat.Struct.Biol.