CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.58.540
Functional Family Botulinum neurotoxin type A

Enzyme Information

3.4.24.69
Bontoxilysin.
based on mapping to UniProt Q45894
Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.
-!- Belongs to peptidase family M27.

UniProtKB Entries (1)

Q45894
BXA2_CLOBJ
Clostridium botulinum A2 str. Kyoto
Botulinum neurotoxin type A2

PDB Structure

PDB 1E1H
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Clostridium Botulinum Neurotoxin Protease in a Product-Bound State: Evidence for Noncanonical Zinc Protease Activity
Segelke, B.W., Knapp, M., Kadhkodayan, S., Balhorn, R., Rupp, B.
Proc.Natl.Acad.Sci.USA