CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydrofolate Reductase, subunit A
Functional Family Dihydrofolate reductase

Enzyme Information

1.5.1.3
Dihydrofolate reductase.
based on mapping to UniProt P00378
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

UniProtKB Entries (1)

P00378
DYR_CHICK
Gallus gallus
Dihydrofolate reductase

PDB Structure

PDB 1DR4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures of Organomercurial-Activated Chicken Liver Dihydrofolate Reductase Complexes
Mctigue, M.A., Davies II, J.F., Kaufman, B.T., Xuong, N.-H., Kraut, J.
To be Published