CATH Classification

Domain Context

CATH Clusters

Superfamily Collagenase (Catalytic Domain)
Functional Family endothelin-converting enzyme 1 isoform X1

Enzyme Information

3.4.24.11
Neprilysin.
based on mapping to UniProt P08473
Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.
-!- A membrane-bound glycoprotein widely distributed in animal tissues. -!- Inhibited by phosphoramidon and thiorphan. -!- Belongs to peptidase family M13.

UniProtKB Entries (1)

P08473
NEP_HUMAN
Homo sapiens
Neprilysin

PDB Structure

PDB 1DMT
External Links
Method X-RAY DIFFRACTION
Organism Saccharomyces
Primary Citation
Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon.
Oefner, C., D'Arcy, A., Hennig, M., Winkler, F.K., Dale, G.E.
J.Mol.Biol.