CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.5.8.2
Trimethylamine dehydrogenase.
based on mapping to UniProt P16099
Trimethylamine + H(2)O + electron-transferring flavoprotein = dimethylamine + formaldehyde + reduced electron-transferring flavoprotein.
-!- A number of alkyl-substituted derivatives of trimethylamine can also act as electron donors. -!- Phenazine methosulfate and 2,6-dichloroindophenol can act as electron acceptors. -!- Formerly EC 1.5.99.7.

UniProtKB Entries (1)

P16099
DHTM_METME
Methylophilus methylotrophus
Trimethylamine dehydrogenase

PDB Structure

PDB 1DJQ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural and biochemical characterization of recombinant wild type and a C30A mutant of trimethylamine dehydrogenase from methylophilus methylotrophus (sp. W(3)A(1)).
Trickey, P., Basran, J., Lian, L.Y., Chen, Z., Barton, J.D., Sutcliffe, M.J., Scrutton, N.S., Mathews, F.S.
Biochemistry