CATH Domain 1dgpB00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.600	Farnesyl Diphosphate Synthase
	1.10.600.10	Farnesyl Diphosphate Synthase

Domain Context

CATH Clusters

Superfamily	Farnesyl Diphosphate Synthase
Functional Family

Enzyme Information

4.2.3.9

Aristolochene synthase.

based on mapping to UniProt Q03471

(2E,6E)-farnesyl diphosphate = aristolochene + diphosphate.

-!- The initial internal cyclization produces the monocyclic intermediate germacrene A; further cyclization and methyl transfer converts the intermediate into aristolochene. -!- While in some species germacrene A remains as an enzyme-bound intermediate, it has been shown to be a minor product of the reaction in Penicillium roqueforti (see also EC 4.2.3.23). -!- Aristolochene is the likely parent compound for a number of sesquiterpenes produced by filamentous fungi. -!- Formerly EC 2.5.1.40 and EC 4.1.99.7.

UniProtKB Entries (1)

Q03471

PRX2_PENRO

Penicillium roqueforti

Aristolochene synthase

PDB Structure

PDB	1DGP
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure determination of aristolochene synthase from the blue cheese mold, Penicillium roqueforti. Caruthers, J.M., Kang, I., Rynkiewicz, M.J., Cane, D.E., Christianson, D.W. J.Biol.Chem.