CATH Classification

Domain Context

CATH Clusters

Superfamily Aspartate Aminotransferase, domain 1
Functional Family Serine hydroxymethyltransferase

Enzyme Information

2.1.2.1
Glycine hydroxymethyltransferase.
based on mapping to UniProt P0A825
5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine.
-!- Also catalyzes the reaction of glycine with acetaldehyde to form L-threonine, and with 4-trimethylammoniobutanal to form 3-hydroxy- N(6),N(6),N(6)-trimethyl-L-lysine.

UniProtKB Entries (1)

P0A825
GLYA_ECOLI
Escherichia coli K-12
Serine hydroxymethyltransferase

PDB Structure

PDB 1DFO
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure at 2.4 A resolution of E. coli serine hydroxymethyltransferase in complex with glycine substrate and 5-formyl tetrahydrofolate.
Scarsdale, J.N., Radaev, S., Kazanina, G., Schirch, V., Wright, H.T.
J.Mol.Biol.