CATH Classification

Domain Context

CATH Clusters

Superfamily EF-hand
Functional Family

Enzyme Information

3.4.22.53
Calpain-2.
based on mapping to UniProt Q07009
Broad endopeptidase specificity.
-!- Cytosolic in animal cells. -!- The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.52. -!- Belongs to peptidase family C2. -!- Formerly EC 3.4.22.17 and EC 3.4.24.5.

UniProtKB Entries (1)

Q64537
CPNS1_RAT
Rattus norvegicus
Calpain small subunit 1

PDB Structure

PDB 1DF0
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of calpain reveals the structural basis for Ca(2+)-dependent protease activity and a novel mode of enzyme activation.
Hosfield, C.M., Elce, J.S., Davies, P.L., Jia, Z.
EMBO J.