CATH Classification

Domain Context

CATH Clusters

Superfamily NADPH-cytochrome p450 Reductase; Chain A, domain 3
Functional Family Sulfite reductase [NADPH] flavoprotein alpha-component

Enzyme Information

1.8.1.2
Assimilatory sulfite reductase (NADPH).
based on mapping to UniProt P38038
H(2)S + 3 NADP(+) + 3 H(2)O = sulfite + 3 NADPH.
-!- The enzyme, which catalyzes the six-electron reduction of sulfite to sulfide, is involved in sulfate assimilation in bacteria and yeast. -!- Different from EC 1.8.99.5, which is involved in prokaryotic sulfur- based energy metabolism. -!- Formerly EC 1.8.99.1.

UniProtKB Entries (1)

P38038
CYSJ_ECOLI
Escherichia coli K-12
Sulfite reductase [NADPH] flavoprotein alpha-component

PDB Structure

PDB 1DDI
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Four crystal structures of the 60 kDa flavoprotein monomer of the sulfite reductase indicate a disordered flavodoxin-like module.
Gruez, A., Pignol, D., Zeghouf, M., Coves, J., Fontecave, M., Ferrer, J.L., Fontecilla-Camps, J.C.
J.Mol.Biol.