CATH Classification

Domain Context

CATH Clusters

Superfamily Transcriptional coactivator/pterin dehydratase
Functional Family Pterin-4-alpha-carbinolamine dehydratase 2

Enzyme Information

4.2.1.96
4a-hydroxytetrahydrobiopterin dehydratase.
based on mapping to UniProt P61459
(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro- 4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro- 6H-pterin + H(2)O.
-!- Catalyzes the dehydration of 4a-hydroxytetrahydrobiopterins.

UniProtKB Entries (1)

P61459
PHS_RAT
Rattus norvegicus
Pterin-4-alpha-carbinolamine dehydratase

PDB Structure

PDB 1DCO
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
High-resolution structures of the bifunctional enzyme and transcriptional coactivator DCoH and its complex with a product analogue.
Cronk, J.D., Endrizzi, J.A., Alber, T.
Protein Sci.