CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.90 | Phospholipase A2 |
|
1.20.90.10 | Phospholipase A2 domain |
Domain Context
CATH Clusters
| Superfamily | Phospholipase A2 domain |
| Functional Family | Basic phospholipase A2 homolog |
Enzyme Information
| 3.1.1.4 |
Phospholipase A(2).
based on mapping to UniProt P14555
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
-!- Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position.
|
UniProtKB Entries (1)
| P14555 |
PA2GA_HUMAN
Homo sapiens
Phospholipase A2, membrane associated
|
PDB Structure
| PDB | 1DB5 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2.
Nat.Struct.Biol.
|