CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family GDP-mannose 4,6 dehydratase

Enzyme Information

4.2.1.47
GDP-mannose 4,6-dehydratase.
based on mapping to UniProt P0AC88
GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H(2)O.
-!- Forms the first step in the biosynthesis of GDP-alpha-D-rhamnose and GDP-alpha-L-fucose. -!- In Aneurinibacillus thermoaerophilus L420-91T, this enzyme acts as a bifunctional enzyme, catalyzing the above reaction as well as the reaction catalyzed by EC 1.1.1.281.

UniProtKB Entries (1)

P0AC88
GM4D_ECOLI
Escherichia coli K-12
GDP-mannose 4,6-dehydratase

PDB Structure

PDB 1DB3
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural and kinetic analysis of Escherichia coli GDP-mannose 4,6 dehydratase provides insights into the enzyme's catalytic mechanism and regulation by GDP-fucose.
Somoza, J.R., Menon, S., Schmidt, H., Joseph-McCarthy, D., Dessen, A., Stahl, M.L., Somers, W.S., Sullivan, F.X.
Structure Fold.Des.