CATH Classification

Domain Context

CATH Clusters

Superfamily 5' to 3' exonuclease, C-terminal subdomain
Functional Family DNA polymerase I

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P00582
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P00582
DPO1_ECOLI
Escherichia coli K-12
DNA polymerase I

PDB Structure

PDB 1D8Y
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural origins of the exonuclease resistance of a zwitterionic RNA.
Teplova, M., Wallace, S.T., Tereshko, V., Minasov, G., Symons, A.M., Cook, P.D., Manoharan, M., Egli, M.
Proc.Natl.Acad.Sci.USA