CATH Classification

Domain Context

CATH Clusters

Superfamily Malate synthase, domain III
Functional Family Malate synthase G

Enzyme Information

2.3.3.9
Malate synthase.
based on mapping to UniProt P37330
Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA.
-!- The enzyme catalyzes the irreversible condensation of acetyl-CoA with glyoxylate to form (S)-malate. -!- Among other functions, the enzyme participates in the glyoxylate cycle, a modified version of the TCA cycle that bypasses steps that lead to a loss of CO(2). -!- Formerly EC 4.1.3.2.

UniProtKB Entries (1)

P37330
MASZ_ECOLI
Escherichia coli K-12
Malate synthase G

PDB Structure

PDB 1D8C
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of Escherichia coli malate synthase G complexed with magnesium and glyoxylate at 2.0 A resolution: mechanistic implications.
Howard, B.R., Endrizzi, J.A., Remington, S.J.
Biochemistry