CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.150 | DNA polymerase; domain 1 |
|
1.10.150.80 | HRDC domain |
Domain Context
CATH Clusters
| Superfamily | HRDC domain |
| Functional Family | ATP-dependent helicase SGS1 |
Enzyme Information
| 3.6.4.12 |
DNA helicase.
based on mapping to UniProt P35187
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).
|
UniProtKB Entries (1)
| P35187 |
SGS1_YEAST
Saccharomyces cerevisiae S288C
ATP-dependent helicase SGS1
|
PDB Structure
| PDB | 1D8B |
| External Links | |
| Method | SOLUTION NMR |
| Organism | Escherichia |
| Primary Citation |
The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins.
Structure Fold.Des.
|