CATH Classification

Domain Context

CATH Clusters

Superfamily Collagenase (Catalytic Domain)
Functional Family Collagenase 3

Enzyme Information

3.4.24.17
Stromelysin 1.
based on mapping to UniProt P08254
Preferential cleavage where P1', P2' and P3' are hydrophobic residues.
-!- Extracellular endopeptidase of vertebrate tissues. -!- Degradation of proteoglycans, fibronectin, collagen type III, IV, V and IX and activates procollagenase. -!- Belongs to peptidase family M10B.

UniProtKB Entries (1)

P08254
MMP3_HUMAN
Homo sapiens
Stromelysin-1

PDB Structure

PDB 1D5J
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Design, synthesis, and biological evaluation of potent thiazine- and thiazepine-based matrix metalloproteinase inhibitors.
Almstead, N.G., Bradley, R.S., Pikul, S., De, B., Natchus, M.G., Taiwo, Y.O., Gu, F., Williams, L.E., Hynd, B.A., Janusz, M.J., Dunaway, C.M., Mieling, G.E.
J.Med.Chem.