CATH Classification

Domain Context

CATH Clusters

Superfamily TPP-binding domain
Functional Family NAD(P) transhydrogenase subunit beta

Enzyme Information

7.1.1.1
Proton-translocating NAD(P)(+) transhydrogenase.
based on mapping to UniProt P11024
NADPH + NAD(+) + H(+)(Side 1) = NADP(+) + H(+)(Side 2) + NADH.
-!- The enzyme is a membrane bound proton-translocating pyridine nucleotide transhydrogenase that couples the reversible reduction of NADP by NADH to an inward proton translocation across the membrane. -!- In the bacterium Escherichia coli the enzyme provides a major source of cytosolic NADPH. -!- Detoxification of reactive oxygen species in mitochondria by glutathione peroxidases depends on NADPH produced by this enzyme. -!- Formerly EC 1.6.1.5.

UniProtKB Entries (1)

P11024
NNTM_BOVIN
Bos taurus
NAD(P) transhydrogenase, mitochondrial

PDB Structure

PDB 1D4O
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of transhydrogenase domain III at 1.2 A resolution.
Prasad, G.S., Sridhar, V., Yamaguchi, M., Hatefi, Y., Stout, C.D.
Nat.Struct.Biol.