CATH Classification

Domain Context

CATH Clusters

Superfamily Medium-chain alcohol dehydrogenases, catalytic domain
Functional Family S-(hydroxymethyl)glutathione dehydrogenase

Enzyme Information

1.1.1.1
Alcohol dehydrogenase.
based on mapping to UniProt P40394
(1) A primary alcohol + NAD(+) = an aldehyde + NADH. (2) A secondary alcohol + NAD(+) = a ketone + NADH.
-!- Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. -!- The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.

UniProtKB Entries (1)

P40394
ADH7_HUMAN
Homo sapiens
Alcohol dehydrogenase class 4 mu/sigma chain

PDB Structure

PDB 1D1S
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Methionine-141 directly influences the binding of 4-methylpyrazole in human sigma sigma alcohol dehydrogenase.
Xie, P.T., Hurley, T.D.
Protein Sci.