CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | L-xylulose reductase |
Enzyme Information
| 1.1.1.184 |
Carbonyl reductase (NADPH).
based on mapping to UniProt P08074
R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
-!- Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol. -!- Si-specific with respect to NADPH (cf. EC 1.1.1.2).
|
UniProtKB Entries (1)
| P08074 |
CBR2_MOUSE
Mus musculus
Carbonyl reductase [NADPH] 2
|
PDB Structure
| PDB | 1CYD |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8 A resolution: the structural origin of coenzyme specificity in the short-chain dehydrogenase/reductase family.
Structure
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