CATH Classification

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P43405
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P43405
KSYK_HUMAN
Homo sapiens
Tyrosine-protein kinase SYK

PDB Structure

PDB 1CSZ
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide.
Narula, S.S., Yuan, R.W., Adams, S.E., Green, O.M., Green, J., Philips, T.B., Zydowsky, L.D., Botfield, M.C., Hatada, M., Laird, E.R., Zoller, M.J., Karas, J.L., Dalgarno, D.C.
Structure