CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family cAMP-dependent protein kinase catalytic subunit alpha

Enzyme Information

2.7.11.11
cAMP-dependent protein kinase.
based on mapping to UniProt P36887
ATP + a protein = ADP + a phosphoprotein.
-!- cAMP is required to activate this enzyme. -!- The inactive holoenzyme of cAMP-dependent protein kinase is a tetramer composed of two regulatory (R) and two catalytic (C) subunits. -!- cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP molecules and two free monomeric catalytic subunits (i.e. R(2)C(2) + 4 cAMP = R(2)(cAMP)(4) + 2 C). -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P36887
KAPCA_PIG
Sus scrofa
CAMP-dependent protein kinase catalytic subunit alpha

PDB Structure

PDB 1CMK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations.
Zheng, J., Knighton, D.R., Xuong, N.H., Taylor, S.S., Sowadski, J.M., Ten Eyck, L.F.
Protein Sci.