CATH Classification

Domain Context

CATH Clusters

Superfamily EF-hand
Functional Family

Enzyme Information

2.7.11.19
Phosphorylase kinase.
based on mapping to UniProt P62158
2 ATP + phosphorylase b = 2 ADP + phosphorylase a.
-!- Requires calmodulin for activity. -!- The enzyme phosphorylates a specific serine residue in each of the subunits of the dimeric phosphorylase b. -!- For muscle phosphorylase but not liver phosphorylase, this is accompanied by a further dimerization to form a tetrameric phosphorylase. -!- The enzyme couples muscle contraction with energy production via glycogenolysis--glycolysis by catalyzing the Ca(2+)-dependent phosphorylation and activation of glycogen phosphorylase b. -!- The gamma subunit of the tetrameric alpha-beta-gamma-delta enzyme is the catalytic subunit. -!- Formerly EC 2.7.1.38.

UniProtKB Entries (0)

PDB Structure

PDB 1CLL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Calmodulin structure refined at 1.7 A resolution.
Chattopadhyaya, R., Meador, W.E., Means, A.R., Quiocho, F.A.
J.Mol.Biol.