CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleic acid-binding proteins
Functional Family

Enzyme Information

2.7.7.50
mRNA guanylyltransferase.
based on mapping to UniProt Q84424
GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA.
-!- Can modify also synthetic poly(A) and poly(G) to form the structures m(7)G(5')pppAn and m(7)G(5')pppGn.

UniProtKB Entries (1)

Q84424
MCE_PBCV1
Paramecium bursaria Chlorella virus 1
MRNA-capping enzyme

PDB Structure

PDB 1CKM
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
X-ray crystallography reveals a large conformational change during guanyl transfer by mRNA capping enzymes.
Hakansson, K., Doherty, A.J., Shuman, S., Wigley, D.B.
Cell(Cambridge,Mass.)