CATH Classification

Domain Context

CATH Clusters

Superfamily FAD/NAD(P)-binding domain
Functional Family NADPH:adrenodoxin oxidoreductase, mitochondrial

Enzyme Information

1.18.1.6
Adrenodoxin-NADP(+) reductase.
based on mapping to UniProt P08165
2 reduced adrenodoxin + NADP(+) = 2 oxidized adrenodoxin + NADPH.
-!- The enzyme, which transfers electrons from NADPH to adrenodoxin molecules, is the first component in the mitochondrial cytochrome P450 electron transfer systems, and is involved in the biosynthesis of all steroid hormones.

UniProtKB Entries (1)

P08165
ADRO_BOVIN
Bos taurus
NADPH:adrenodoxin oxidoreductase, mitochondrial

PDB Structure

PDB 1CJC
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The structure of adrenodoxin reductase of mitochondrial P450 systems: electron transfer for steroid biosynthesis.
Ziegler, G.A., Vonrhein, C., Hanukoglu, I., Schulz, G.E.
J.Mol.Biol.