CATH Classification

Domain Context

CATH Clusters

Superfamily Ricin (A subunit), domain 1
Functional Family

Enzyme Information

3.2.2.22
rRNA N-glycosylase.
based on mapping to UniProt P24817
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P24817
RIP3_MOMCH
Momordica charantia
Ribosome-inactivating protein beta-momorcharin

PDB Structure

PDB 1CF5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Three-dimensional structure of beta-momorcharin at 2.55 A resolution.
Yuan, Y.R., He, Y.N., Xiong, J.P., Xia, Z.X.
Acta Crystallogr.,Sect.D