CATH Classification
Domain Context
CATH Clusters
| Superfamily | Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal |
| Functional Family | L-lactate dehydrogenase |
Enzyme Information
| 1.1.1.27 |
L-lactate dehydrogenase.
based on mapping to UniProt Q27743
(S)-lactate + NAD(+) = pyruvate + NADH.
-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.
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UniProtKB Entries (1)
| Q27743 |
LDH_PLAFD
Plasmodium falciparum CDC/Honduras
L-lactate dehydrogenase
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PDB Structure
| PDB | 1CET |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Chloroquine binds in the cofactor binding site of Plasmodium falciparum lactate dehydrogenase.
J.Biol.Chem.
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