CATH Classification

Domain Context

CATH Clusters

Superfamily Plasminogen Kringle 4
Functional Family

Enzyme Information

3.4.21.7
Plasmin.
based on mapping to UniProt P00747
Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products.
-!- Formed from plasminogen by proteolysis which results in multiple forms of the active plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.14.

UniProtKB Entries (1)

P00747
PLMN_HUMAN
Homo sapiens
Plasminogen

PDB Structure

PDB 1CEB
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of the recombinant kringle 1 domain of human plasminogen in complexes with the ligands epsilon-aminocaproic acid and trans-4-(aminomethyl)cyclohexane-1-carboxylic Acid.
Mathews, I.I., Vanderhoff-Hanaver, P., Castellino, F.J., Tulinsky, A.
Biochemistry