CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Alcohol dehydrogenase 1

Enzyme Information

1.1.1.1
Alcohol dehydrogenase.
based on mapping to UniProt P26325
(1) A primary alcohol + NAD(+) = an aldehyde + NADH. (2) A secondary alcohol + NAD(+) = a ketone + NADH.
-!- Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. -!- The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.

UniProtKB Entries (1)

P26325
ADH1_GADMC
Gadus morhua callarias
Alcohol dehydrogenase 1

PDB Structure

PDB 1CDO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of cod liver class I alcohol dehydrogenase: substrate pocket and structurally variable segments.
Ramaswamy, S., el Ahmad, M., Danielsson, O., Jornvall, H., Eklund, H.
Protein Sci.