CATH Domain 1ca1A02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.60	Lipoxygenase-1
	2.60.60.20	PLAT/LH2 domain

Domain Context

CATH Clusters

Superfamily	PLAT/LH2 domain
Functional Family

Enzyme Information

3.1.4.3

Phospholipase C.

based on mapping to UniProt P0C216

A phosphatidylcholine + H(2)O = 1,2-diacyl-sn-glycerol + phosphocholine.

-!- The bacterial enzyme also acts on sphingomyelin and phosphatidylinositol. -!- The enzyme from seminal plasma does not act on phosphatidylinositol.

UniProtKB Entries (1)

P0C216

PHLC1_CLOPE

Clostridium perfringens str. 13

Phospholipase C

PDB Structure

PDB	1CA1
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structure of the key toxin in gas gangrene. Naylor, C.E., Eaton, J.T., Howells, A., Justin, N., Moss, D.S., Titball, R.W., Basak, A.K. Nat.Struct.Biol.