CATH Classification

Domain Context

CATH Clusters

Superfamily TolB, C-terminal domain
Functional Family

Enzyme Information

1.1.5.2
Quinoprotein glucose dehydrogenase (PQQ, quinone).
based on mapping to UniProt P13650
D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol.
-!- Integral membrane protein containing PQQ as prosthetic group. -!- It also contains bound ubiquinone and Mg(2+) or Ca(2+). -!- Electron acceptor is membrane ubiquinone but usually assayed with phenazine methosulfate. -!- Like in all other quinoprotein alcohol dehydrogenases the catalytic domain has an 8-bladed 'propeller' structure. -!- It occurs in a wide range of bacteria. -!- Catalyzes a direct oxidation of the pyranose form of D-glucose to the lactone and thence to D-gluconate in the periplasm. -!- Oxidizes other monosaccharides including the pyranose forms of pentoses. -!- Formerly EC 1.1.99.17.

UniProtKB Entries (1)

P13650
DHGB_ACICA
Acinetobacter calcoaceticus
Quinoprotein glucose dehydrogenase B

PDB Structure

PDB 1C9U
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure and mechanism of soluble quinoprotein glucose dehydrogenase.
Oubrie, A., Rozeboom, H.J., Kalk, K.H., Olsthoorn, A.J., Duine, J.A., Dijkstra, B.W.
EMBO J.