CATH Classification

Domain Context

CATH Clusters

Superfamily Protein tyrosine phosphatase superfamily
Functional Family Tyrosine-protein phosphatase non-receptor type 1

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt P18031
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

P18031
PTN1_HUMAN
Homo sapiens
Tyrosine-protein phosphatase non-receptor type 1

PDB Structure

PDB 1C86
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B.
Iversen, L.F., Andersen, H.S., Branner, S., Mortensen, S.B., Peters, G.H., Norris, K., Olsen, O.H., Jeppesen, C.B., Lundt, B.F., Ripka, W., Moller, K.B., Moller, N.P.
J.Biol.Chem.