CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphoglycerate mutase-like
Functional Family 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 variant 4

Enzyme Information

2.7.1.105
6-phosphofructo-2-kinase.
based on mapping to UniProt P07953
ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.
-!- Not identical with EC 2.7.1.11. -!- The enzyme copurifies with EC 3.1.3.46.
3.1.3.46
Fructose-2,6-bisphosphate 2-phosphatase.
based on mapping to UniProt P07953
Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.
-!- The enzyme copurifies with EC 2.7.1.105 (cf. EC 3.1.3.54).

UniProtKB Entries (1)

P07953
F261_RAT
Rattus norvegicus
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

PDB Structure

PDB 1C7Z
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Reaction Mechanism of Fructose-2,6-bisphosphatase Suggested by the Crystal Structures of a pseudo-Michaelis complex and Metabolite Complexes
Lee, Y.-H., Olson, T.W., McClard, R.W., Witte, J.F., McFarlan, S.C., Banaszak, L.J., Levitt, D.G., Lange, A.J.
To be Published