CATH Classification

Domain Context

CATH Clusters

Superfamily 5' to 3' exonuclease, C-terminal subdomain
Functional Family Holliday junction ATP-dependent DNA helicase RuvA

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt P0A809
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

P0A809
RUVA_ECOLI
Escherichia coli K-12
Holliday junction ATP-dependent DNA helicase RuvA

PDB Structure

PDB 1C7Y
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of the holliday junction DNA in complex with a single RuvA tetramer.
Ariyoshi, M., Nishino, T., Iwasaki, H., Shinagawa, H., Morikawa, K.
Proc.Natl.Acad.Sci.USA