CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Urokinase-type plasminogen activator

Enzyme Information

3.4.21.73
U-plasminogen activator.
based on mapping to UniProt P00749
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
-!- Formed from the inactive precursor by action of plasmin or plasma kallikrein. -!- Differs in structure from EC 3.4.21.68, and does not bind to fibrin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.21.31 and EC 3.4.99.26.

UniProtKB Entries (1)

P00749
UROK_HUMAN
Homo sapiens
Urokinase-type plasminogen activator

PDB Structure

PDB 1C5X
External Links
Method X-RAY DIFFRACTION
Organism Pichia
Primary Citation
Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Chem.Biol.