CATH Classification

Domain Context

CATH Clusters

Superfamily SCP2 sterol-binding domain
Functional Family

Enzyme Information

2.3.1.176
Propanoyl-CoA C-acyltransferase.
based on mapping to UniProt O62742
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3-alpha,7-alpha,12-alpha-trihydroxy-24-oxo-5-beta-cholestanoyl- CoA.
-!- Also acts on dihydroxy-5-beta-cholestanoyl-CoA and other branched chain acyl-CoA derivatives. -!- Catalyzes the penultimate step in the formation of bile acids. -!- The bile acid moiety is transferred from the acyl-CoA thioester (RCO- SCoA) to either glycine or taurine (NH(2)R') by EC 2.3.1.65. -!- Formerly EC 2.3.1.154.

UniProtKB Entries (1)

O62742
NLTP_RABIT
Oryctolagus cuniculus
Non-specific lipid-transfer protein

PDB Structure

PDB 1C44
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of sterol carrier protein 2 at 1.8 A resolution reveals a hydrophobic tunnel suitable for lipid binding.
Choinowski, T., Hauser, H., Piontek, K.
Biochemistry