CATH Domain 1c0mA02

×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.30	Roll
	2.30.30	SH3 type barrels.
	2.30.30.10	Integrase, C-terminal domain superfamily, retroviral

Domain Context

CATH Clusters

Superfamily	Integrase, C-terminal domain superfamily, retroviral
Functional Family

Enzyme Information

3.1.-.-	Acting on ester bonds. based on mapping to UniProt P03354
3.4.23.-	Aspartic endopeptidases. based on mapping to UniProt P03354
3.1.26.4	Ribonuclease H. based on mapping to UniProt P03354 Endonucleolytic cleavage to 5'-phosphomonoester. -!- Acts on RNA-DNA hybrids.
2.7.7.49	RNA-directed DNA polymerase. based on mapping to UniProt P03354 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.
2.7.7.-	Nucleotidyltransferases. based on mapping to UniProt P03354
2.7.7.7	DNA-directed DNA polymerase. based on mapping to UniProt P03354 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

POL_RSVP

Rous sarcoma virus - Prague C

Gag-Pol polyprotein

PDB Structure

PDB	1C0M
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of an active two-domain derivative of Rous sarcoma virus integrase. Yang, Z.N., Mueser, T.C., Bushman, F.D., Hyde, C.C. J.Mol.Biol.