CATH Classification

Domain Context

CATH Clusters

Superfamily DNA helicase RuvA subunit, C-terminal domain
Functional Family

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt P40832
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

P40832
RUVA_MYCLE
Mycobacterium leprae TN
Holliday junction ATP-dependent DNA helicase RuvA

PDB Structure

PDB 1BVS
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of an octameric RuvA-Holliday junction complex.
Roe, S.M., Barlow, T., Brown, T., Oram, M., Keeley, A., Tsaneva, I.R., Pearl, L.H.
Mol.Cell