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CATH Classification

Domain Context

CATH Clusters

Superfamily Ricin (A Subunit), domain 2
Functional Family

Enzyme Information

3.2.2.22
rRNA N-glycosylase.
based on mapping to UniProt P33185
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P33185
RIP1_BRYDI
Bryonia dioica
Ribosome-inactivating protein bryodin I

PDB Structure

PDB 1BRY
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Molecular, biological, and preliminary structural analysis of recombinant bryodin 1, a ribosome-inactivating protein from the plant Bryonia dioica.
Gawlak, S.L., Neubauer, M., Klei, H.E., Chang, C.Y., Einspahr, H.M., Siegall, C.B.
Biochemistry
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