CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.35 | Fructose Permease |
|
3.40.35.10 | Phosphotransferase system, sorbose subfamily IIB component |
Domain Context
CATH Clusters
| Superfamily | Phosphotransferase system, sorbose subfamily IIB component |
| Functional Family |
Enzyme Information
| 2.7.1.202 |
Protein-N(pi)-phosphohistidine--D-fructose phosphotransferase.
based on mapping to UniProt P26380
[Protein]-N(pi)-phospho-L-histidine + D-fructose(Side 1) = [protein]-L- histidine + D-fructose 1-phosphate(Side 2).
-!- This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). -!- The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. -!- The phosphate donor, which is shared among the different systems, is usually a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9. -!- The enzyme from the bacterium Escherichia coli is an exception, since it is phosphorylated directly by EC 2.7.3.9. -!- The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate. -!- Formerly EC 2.7.1.69.
|
UniProtKB Entries (1)
| P26380 |
PTFB_BACSU
Bacillus subtilis subsp. subtilis str. 168
PTS system fructose-specific EIIB component
|
PDB Structure
| PDB | 1BLE |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Bacillus |
| Primary Citation |
Crystal structure of the IIB subunit of a fructose permease (IIBLev) from Bacillus subtilis.
J.Mol.Biol.
|