CATH Classification

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family Proto-oncogene tyrosine-protein kinase Src

Enzyme Information
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P00524
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC

UniProtKB Entries (1)

Rous sarcoma virus (strain Schmidt-Ruppin A)
Tyrosine-protein kinase transforming protein Src

PDB Structure

External Links
Organism Escherichia
Primary Citation
Novel Pp60Src Sh2 Domain Crystal Structures: A 2.0 Angstrom Co-Crystal Structure of a D-Amino Acid Substituted Phosphopeptide Complex and a 2.1 Angstrom Apo Structure Displaying Self-Association
Holland, D.R., Lunney, E.A., Plummer, M.S., Mueller, W.T., Mcconnell, P., Pavlovsky, A., Para, K.S., Shahripour, A., Humblet, C., Sawyer, T.K., Rubin, J.R.
To be Published