CATH Classification

Domain Context

CATH Clusters

Superfamily NADH Oxidase
Functional Family

Enzyme Information

1.5.1.38
FMN reductase (NADPH).
based on mapping to UniProt Q56691
FMNH(2) + NADP(+) = FMN + NADPH.
-!- The enzymes from bioluminescent bacteria contain FMN, while the enzyme from Escherichia coli does not. -!- The enzyme often forms a two-component system with monooxygenases such as luciferase. -!- Unlike EC 1.5.1.39, this enzyme does not use NADH as acceptor. -!- While FMN is the preferred substrate, the enzyme can also use FAD and riboflavin with lower activity. -!- Formerly EC 1.5.1.29 and EC 1.6.8.1.

UniProtKB Entries (1)

Q56691
FRP_VIBHA
Vibrio harveyi
NADPH-flavin oxidoreductase

PDB Structure

PDB 1BKJ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Flavin reductase P: structure of a dimeric enzyme that reduces flavin.
Tanner, J.J., Lei, B., Tu, S.C., Krause, K.L.
Biochemistry